Psilocybin and LSD Shown to Reduce Cluster Headaches

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Psilocybin and LSD Shown to Reduce Cluster Headaches

Cluster headaches are often viewed to be the most painful headaches anyone can experience.  The authors interviewed 53 cluster headache patients who had used psilocybin or lysergic acid diethylamide (LSD) to treat their condition. 22 of 26 psilocybin users reported that psilocybin aborted attacks; 25 of 48 psilocybin users and 7 of 8 LSD users reported cluster period termination; 18 of 19 psilocybin users and 4 of 5 LSD users reported remission period extension. Why is this an amazing find?

This is amazing for three great reasons: 

1) No other medication, to our knowledge, has been reported to terminate a cluster period.

2) Unlike other ergot-based medications, which must be taken daily, a single dose of LSD was described as sufficient to induce remission of a cluster headache and psilocybin rarely required more than three doses.

3) Given the apparent efficacy of sub-hallucinogenic doses, these drugs might benefit cluster headache by a mechanism unrelated to their psychoactive effects

Future research is warranted.

Source

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